4-Trifluoromethyl-1,2-phenylenediamine → HCID 178455650, compound

HRID 639429Notes

Reaction equation

HRID 639429 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[F:15])[N:3]=1.[C:16]([S:20]([NH:23][C@@H:24]1[CH2:29][CH2:28][C@H:27]([C:30](O)=O)[CH2:26][CH2:25]1)(=[O:22])=[O:21])([CH3:19])([CH3:18])[CH3:17].N[C@@H]1CC[C@H](C(O)=O)CC1.FC(F)(F)C1C=CC(N)=C(N)C=1>>[C:16]([S:20]([NH:23][C@@H:24]1[CH2:25][CH2:26][C@H:27]([C:30]2[NH:8][C:7]3[C:2](=[N:3][C:4]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=4[F:15])=[N:5][CH:6]=3)[N:1]=2)[CH2:28][CH2:29]1)(=[O:22])=[O:21])([CH3:19])([CH3:17])[CH3:18]

Participants

5

Reactant 4

HCID 5208224-Trifluoromethyl-1,2-phenylenediamineHCID 231541712-(2-Fluorophenyl)-4,5-pyrimidinediamineHCID 178455654HCID 178455654, compoundHCID 178511566HCID 178511566, compound

Product 1

HCID 178455650HCID 178455650, compound

Procedure

By following the same procedure as described in Example 1 except that use was made of 4,5-diamino-2-(2-florophenyl)-pyrimidine and cis-4-tert-butylsulfonylaminocyclohexane-carboxylic acid as prepared from cis-4-aminocyclohexane-carboxylic acid in accordance with the 1st, 2nd and 4th steps of Example 4 described in WO0137826 in place of 4-trifluoromethyl-1,2-phenylenediamine, the title compound was prepared.

Sources & evidence

ORD record
ord-eb047dd0e2164b5e8e500cc0c90c3599
Source dataset
uspto-grants-2010_04
Patent number
US07691860B2

Reaction notes

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