(1,1'-Biphenyl)-3,4-diamine → HCID 178484789, compound

HRID 639434Notes

Reaction equation

HRID 639434 reaction equation
[CH3:1][N:2]([S:12]([C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:14])=[O:13])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9](O)=O)[CH2:5][CH2:4]1.[C:19]1([C:25]2[CH:30]=[CH:29][C:28]([NH2:31])=[C:27]([NH2:32])[CH:26]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:1][N:2]([S:12]([C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:14])=[O:13])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]2[NH:32][C:27]3[CH:26]=[C:25]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:30]=[CH:29][C:28]=3[N:31]=2)[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 6452000(1,1'-Biphenyl)-3,4-diamineHCID 178484816HCID 178484816, compound

Product 1

HCID 178484789HCID 178484789, compound

Procedure

Trans-4-(N-methyl-tert-butylsulfonylamino)cyclohexanecarboxylic acid and 4-phenyl-1,2-phenylenediamine were allowed to undergo ring closure condensation under the same conditions as described in Example 1-3), followed by separatory purification on a collective thin-layer chromatograph (chloroform:methanol=10:1) to give the title compound.

Workup

  1. customring closure condensation under the same conditions
  2. customfollowed by separatory purification on a collective thin-layer chromatograph (chloroform:methanol=10:1)

Sources & evidence

ORD record
ord-de5f2605f979439c852160bc03a80a9d
Source dataset
uspto-grants-2010_04
Patent number
US07691860B2

Reaction notes

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