Cis-2-boc-hexahydropyrrolo[3,4-C]pyrrole → HCID 68428008, compound

Participants

Reaction Conditions

Reaction Steps

2-Chloro-5-phenylbenzimidazole (34 mg) was added to the N-methylpyrrolidone solution (0.2 mL) containing 3-tert-butoxycarbonyl-cis-3,7-diazabicyclo[3.3.0]octane (62 mg), followed by stirring at 150° C. for 4 hrs. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was separated and purified on a silica-gel column chromatograph (C-300, chloroform:THF=4:1) to give the title compound (29 mg).

Provenance & Evidence