1,4-Dioxane hydrochloride → HCID 68428151, compound

HRID 639438Notes

Reaction equation

HRID 639438 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:22][C@@H:21]2[C@@H:17]([CH2:18][N:19]([C:23]3[NH:24][C:25]4[CH:31]=[C:30]([C:32]5[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=5)[CH:29]=[CH:28][C:26]=4[N:27]=3)[CH2:20]2)[CH2:16]1)=O)(C)(C)C>>[ClH:1].[C@@H:17]12[CH2:16][NH:15][CH2:22][C@@H:21]1[CH2:20][N:19]([C:23]1[NH:24][C:25]3[CH:31]=[C:30]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH:29]=[CH:28][C:26]=3[N:27]=1)[CH2:18]2

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68428008HCID 68428008, compound

Product 1

HCID 68428151HCID 68428151, compound

Procedure

4N Hydrochloric acid/dioxane solution (1 mL) was added to 2-(3-tert-butoxycarbonyl-cis-3,7-diazabicyclo[3.3.0]oct-7-yl)-5-phenylbenzimidazole (26 mg), followed by stirring at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (26 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a6d5ebefd37b452391911fb30e61384b
Source dataset
uspto-grants-2010_04
Patent number
US07691860B2

Reaction notes

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