(Methylsulfonyl)(2-Piperazinylphenyl)Amine → 8-{1-(2-Methylsulfonylaminophenyl)piperazin-4-yl}-2-phenylpurine

HRID 639440Notes

Reaction equation

HRID 639440 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)(=[O:4])=[O:3].Cl[C:19]1[NH:27][C:26]2[C:21](=[N:22][C:23]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[N:24][CH:25]=2)[N:20]=1>>[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][N:15]([C:19]2[NH:27][C:26]3[C:21](=[N:22][C:23]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[N:24][CH:25]=3)[N:20]=2)[CH2:14][CH2:13]1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 19261360(Methylsulfonyl)(2-Piperazinylphenyl)AmineHCID 231541768-Chloro-2-phenylpurine

Product 1

HCID 112130718-{1-(2-Methylsulfonylaminophenyl)piperazin-4-yl}-2-phenylpurine

Procedure

By following the same reaction as described in Example 19 except that 1-(2-methylsulfonylaminophenyl)piperazine was used in place of 3-tert-butoxycarbonyl-cis-3,7-diazabicyclo[3.3.0]octane, and 8-chloro-2-phenylpurine was used in place of 2-chloro-5-phenylbenzimidazole, the title compound was prepared.

Workup

  1. customthe same reaction

Sources & evidence

ORD record
ord-44dcce2e172448c0ad3ca7fb98b021c5
Source dataset
uspto-grants-2010_04
Patent number
US07691860B2

Reaction notes

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