3-Chloropropanesulphonyl chloride → HCID 3752540, compound

HRID 639441Notes

Reaction equation

HRID 639441 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][S:5](Cl)(=[O:7])=[O:6].[NH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12][CH2:11]1>CCOCC>[Cl:1][CH2:2][CH2:3][CH2:4][S:5]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12][CH2:11]1)(=[O:7])=[O:6]

Participants

4

Reactant 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 4158521-Benzyl-4-piperidylamine

Product 1

HCID 3752540HCID 3752540, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3-Chloropropanesulfonyl chloride (0.26 mL) was added to the ether solution (10 mL) containing 4-amino-1-benzylpiperidine (400 mg) at 0° C., followed by stirring for 3 hrs. The reaction mixture was concentrated under reduced pressure to give the title compound (678 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0775b8263f804961b567f95f14efc84f
Source dataset
uspto-grants-2010_04
Patent number
US07691860B2

Reaction notes

Loading…