反应详情

A sample of the product from Example 1 may be dissolved in a mixture of methanol and dichloromethane (1:1) loaded onto a Chiralpak IC column (250×20 mm internal diameter) and eluted with methanol/CO2 (60:40) at ambient temperature and a flow rate of 60 g/min. Fractions containing a single enantiomer may be combined and evaporated under reduced pressure to give the product enantiomer. Chiral purity may be assessed by chiral hplc using a Chiralpak IC column eluting with hexane/isopropanol.

1. washeluted with methanol/CO2 (60:40) at ambient temperature
2. additionFractions containing a single enantiomer
3. customevaporated under reduced pressure
4. customto give the product enantiomer
5. washeluting with hexane/isopropanol