Hydrochloric Acid → HCID 68578451, compound

Participants

Reaction Steps

To a stirred solution of 3-Ethylmorphinan.HCl 46 (3 mg, 0.01 mmol) in dry DMF (0.6 mL) was added potassium carbonate (5 mg, 0.036 mmol), allyl bromide (5.0 μL, 0.060 mmol) sequentially and the mixture was refluxed. After 2 h, the mixture was dried over anhydrous MgSO4, filtered, and concentrated. Column chromatography of the product gave -2 mg of white solid. 1H NMR (300 MHz, CDCl3) δ 6.89˜7.16 (3H, m); 5.80 (1H, d); 5.16˜5.30 (2H, m); 4.00˜4.30 (1H, dd); 3.68 (2H, t); 3.66 (1H, m); 3.15 (1H, br); 2.68 (2H, m); 2.50 (2H, m); 2.38 (1H, m); 1.10˜1.70 (13H, m).

Provenance & Evidence