Hydrochloric Acid → HCID 68576837, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-phenylcarbamoyloxymorphinan.HCl 30 (2.8 mg, 0.007 mmol) in dry DMF (0.15 mL) was added potassium carbonate (5.4 mg, 0.021 mmol), 1-bromo-3-chloropropane (1.9 μL, 0.042 mmol) sequentially and the mixture was stirred at 50° C. After starting material disappeared on TLC, solvent was concentrated and column chromatography gave 2.1 mg (70%) of the title compound: 1H NMR (300 MHz, CDCl3) δ7.35 (4H, m); 7.10 (2H, m); 6.85 (1H, d); 6.75 (1H, d.d.); 6.28 (1H, s); 4.38 (1H, m); 4.10 (2H, t); 3.80 (2H, t); 3.65 (1H, m); 3.14 (1H, d.d.); 2.83 (2H, m); 2.37 (1H, m); 2.25 (2H, m); 1.00˜1.80 (10H, m).

Provenance & Evidence