Dimethylformamide dimethyl acetal → (2E)-1-[2-(allyloxy)-4-methylphenyl]-3-(dimethylamino)prop-2-en-1-one

HRID 63958Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 63958
[CH2:1]([O:4][C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[C:12](=[O:14])[CH3:13])[CH:2]=[CH2:3].CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH2:1]([O:4][C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[C:12](=[O:14])/[CH:13]=[CH:17]/[N:18]([CH3:20])[CH3:19])[CH:2]=[CH2:3]

Komponenten

3

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 607470631-[2-(Allyloxy)-4-methylphenyl]ethanone

Produkt 1

HCID 69672943(2E)-1-[2-(allyloxy)-4-methylphenyl]-3-(dimethylamino)prop-2-en-1-one

Versuchsvorschrift

To 1-[2-(allyloxy)-4-methylphenyl]ethanone (Step 1, 13.9 g, 73 mmol) was added dimethylformamide dimethylacetal (56 mL, 422 mmol), and the reaction was heated to reflux for 18 hours. The reaction was then concentrated in vacuo to give the title compound as an orange oil, 17.9 g, which was taken crude into the next reaction.

Aufarbeitung

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 18 hours
  3. concentrationThe reaction was then concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4322e6a25cec4c549989bedac1e82cc0
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447116B2

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