Ammonia → HCID 178516635, compound

Participants

Reaction Steps

6-Cyclopropyl-2,4-dihydroxy-nicotinic acid ethyl ester (5.3 g, 20.5 mmol) was dissolved in concentrated HCl (25 mL) and the mixture was refluxed overnight. The mixture was cooled to room temperature and then neutralised with concentrated ammonia. The resulting precipitate was collected by filtration, washed with cold water and acetonitrile and dried in vacuo at 40° C. over 2 days to give the title compound (3.39 g) as a beige powder.

Provenance & Evidence