(2-Benzylamino-3-nitro-6-trifluoromethyl-pyridin-4-yl)-carbamic acid ethyl ester → (3-Amino-2-benzylamino-6-trifluormethyl-pyridin-4-yl)-carbamic acid ethyl ester

Participants

Reaction Steps

(2-benzylamino-3-nitro-6-trifluormethyl-pyridin-4-yl)-carbamic acid ethyl ester (95 mg, 0.25 mmol) was dissolved in 10 mL of ethanol and Raney Nickel (20 mg, 20% MW) was added then the reaction mixture was stirred at room temperature in a bomb under 50 PSI of hydrogen for 2 h. The mixture was filtered through arbocel and the filtrate was concentrated in vacuo to give 88 mg of the title compound as a pale green gum.

Provenance & Evidence