5-Ethyl-1,3-oxazole → [2-Amino-6-(5-ethyl-oxazol-2-yl)-3-nitro-pyridin-4-yl]-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

HRID 639651Notes

Reaction equation

HRID 639651 reaction equation
[CH2:1]([C:3]1[O:7][CH:6]=[N:5][CH:4]=1)[CH3:2].[CH2:8]([O:10][C:11](=[O:32])[N:12]([C:21]1[CH:26]=[C:25](Br)[N:24]=[C:23]([NH2:28])[C:22]=1[N+:29]([O-:31])=[O:30])[CH2:13][C:14]1[CH:15]=[N:16][C:17]([CH3:20])=[CH:18][CH:19]=1)[CH3:9]>>[CH2:8]([O:10][C:11](=[O:32])[N:12]([C:21]1[CH:26]=[C:25]([C:6]2[O:7][C:3]([CH2:1][CH3:2])=[CH:4][N:5]=2)[N:24]=[C:23]([NH2:28])[C:22]=1[N+:29]([O-:31])=[O:30])[CH2:13][C:14]1[CH:15]=[N:16][C:17]([CH3:20])=[CH:18][CH:19]=1)[CH3:9]

Participants

3

Reactant 2

HCID 122141135-Ethyl-1,3-oxazoleHCID 86614483(2-Amino-6-bromo-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

Product 1

HCID 67455778[2-Amino-6-(5-ethyl-oxazol-2-yl)-3-nitro-pyridin-4-yl]-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

Procedure

The title compound was prepared following the example in preparation 70, using 5-ethyl-oxazole (47 mg) and (2-amino-6-bromo-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester (100 mg), giving the product (79 mg) as a yellow gum.

Workup

  1. customin preparation 70

Sources & evidence

ORD record
ord-4310d2f1de2e46cfacc886026a632203
Source dataset
uspto-grants-2010_04
Patent number
US07691877B2

Reaction notes

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