4,5-Dimethyloxazole → [2-Amino-6-(4,5-dimethyl-oxazol-2-yl)-3-nitro-pyridin-4-yl]-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

HRID 639654Notes

Reaction equation

HRID 639654 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[CH3:7].[CH2:8]([O:10][C:11](=[O:32])[N:12]([C:21]1[CH:26]=[C:25](Br)[N:24]=[C:23]([NH2:28])[C:22]=1[N+:29]([O-:31])=[O:30])[CH2:13][C:14]1[CH:15]=[N:16][C:17]([CH3:20])=[CH:18][CH:19]=1)[CH3:9]>>[CH2:8]([O:10][C:11](=[O:32])[N:12]([C:21]1[CH:26]=[C:25]([C:4]2[O:5][C:6]([CH3:7])=[C:2]([CH3:1])[N:3]=2)[N:24]=[C:23]([NH2:28])[C:22]=1[N+:29]([O-:31])=[O:30])[CH2:13][C:14]1[CH:15]=[N:16][C:17]([CH3:20])=[CH:18][CH:19]=1)[CH3:9]

Participants

3

Reactant 2

HCID 302144,5-DimethyloxazoleHCID 86614483(2-Amino-6-bromo-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

Product 1

HCID 67457304[2-Amino-6-(4,5-dimethyl-oxazol-2-yl)-3-nitro-pyridin-4-yl]-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester

Procedure

The title compound was prepared following the example in preparation 70, using 4,5-dimethyl-oxazole (47 mg) and (2-amino-6-bromo-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester (100 mg), giving the product (75 mg) as a yellow gum.

Workup

  1. customin preparation 70

Sources & evidence

ORD record
ord-bb7c92f3a76d498783b06eae5b58b8f5
Source dataset
uspto-grants-2010_04
Patent number
US07691877B2

Reaction notes

Loading…