HCID 67457797, compound → HCID 67457141, compound

HRID 639664Notes

Reaction equation

HRID 639664 reaction equation
[CH3:1][N:2]([CH3:9])[CH2:3][C:4]1[N:5]=[CH:6][O:7][CH:8]=1.[CH2:10]([O:12][C:13](=[O:33])[N:14]([C:22]1[CH:27]=[C:26](Br)[N:25]=[C:24]([NH2:29])[C:23]=1[N+:30]([O-:32])=[O:31])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:11]>[Cl-].[Cl-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Pd+2]>[CH2:10]([O:12][C:13](=[O:33])[N:14]([C:22]1[CH:27]=[C:26]([C:6]2[O:7][CH:8]=[C:4]([CH2:3][N:2]([CH3:9])[CH3:1])[N:5]=2)[N:25]=[C:24]([NH2:29])[C:23]=1[N+:30]([O-:32])=[O:31])[CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH3:11]

Participants

4

Reactant 2

HCID 67457797HCID 67457797, compoundHCID 86614485(2-Amino-6-bromo-3-nitro-pyridin-4-yl)-benzyl-carbamic acid ethyl ester

Product 1

HCID 67457141HCID 67457141, compound

Reagents, catalysts & solvents 1

HCID 84124Bis(triphenylphosphine)palladium chlorideCatalyst

Procedure

The title compound was prepared following the example in preparation 70, using dimethyl-oxazol-4-ylmethyl-amine (128 mg), (2-amino-6-bromo-3-nitro-pyridin-4-yl)-benzyl-carbamic acid ethyl ester (200 mg) and palladium bis(triphenylphosphine)dichloride (71 mg), giving the product (99 mg) as a yellow gum.

Workup

  1. customin preparation 70

Sources & evidence

ORD record
ord-7ff79961d74b4f4086622eeead55841c
Source dataset
uspto-grants-2010_04
Patent number
US07691877B2

Reaction notes

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