Ammonia → (2-Amino-6-bromo-3-nitro-pyridin-4-yl)-(3-cyano-benzyl)-carbamic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:26])[N:5]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]#[N:25])[CH:19]=1)[C:6]1[CH:11]=[C:10]([Br:12])[N:9]=[C:8](Br)[C:7]=1[N+:14]([O-:16])=[O:15])[CH3:2].[NH3:27]>>[CH2:1]([O:3][C:4](=[O:26])[N:5]([C:6]1[CH:11]=[C:10]([Br:12])[N:9]=[C:8]([NH2:27])[C:7]=1[N+:14]([O-:16])=[O:15])[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]#[N:25])[CH:19]=1)[CH3:2]Participants
3
Procedure
The title compound was prepared following the example in preparation 68 using (3-cyano-benzyl)-(2,6-dibromo-3-nitro-pyridin-4-yl)-carbamic acid ethyl ester (2.32 g), aqueous ammonia (10.2 ml), and 2-methyl-THF (10.2 ml). This gave the product (1.51 g) as a yellow solid.
Sources & evidence
- ORD record
- ord-4c7d1c3a69f843098acf8dce67600441
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07691877B2
Reaction notes
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