HCID 67457151, compound → HCID 67455750, compound

HRID 639678Notes

Reaction equation

HRID 639678 reaction equation
[CH2:1]([O:3][C:4](=[O:28])[N:5]([C:13]1[CH:18]=[C:17]([N:19]2[CH:23]=[CH:22][CH:21]=[N:20]2)[N:16]=[C:15]([NH2:24])[C:14]=1[N+:25]([O-])=O)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2]>CO.[Ni]>[CH2:1]([O:3][C:4](=[O:28])[N:5]([CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[C:13]1[CH:18]=[C:17]([N:19]2[CH:23]=[CH:22][CH:21]=[N:20]2)[N:16]=[C:15]([NH2:24])[C:14]=1[NH2:25])[CH3:2]

Participants

4

Reactant 1

HCID 67457151HCID 67457151, compound

Product 1

HCID 67455750HCID 67455750, compoundYield 96.3%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

(2-Amino-3-nitro-6-pyrazol-1-yl-pyridin-4-yl)-benzyl-carbamic acid ethyl ester (65.4 mg, 0.171 mmol) was dissolved in methanol (5 mL) and hydrogenated over Raney Nickel (25 mg) at room temperature, 80 psi for 1 hour. The reaction mixture was filtered through a short plug of Arbocel and the filtrate was then evaporated in vacuo to afford 58mg of the title compound as a brown residue.

Workup

  1. filtrationThe reaction mixture was filtered through a short plug of Arbocel
  2. customthe filtrate was then evaporated in vacuo

Sources & evidence

ORD record
ord-04cd9a93e2d14c9eac60063c5b020a66
Source dataset
uspto-grants-2010_04
Patent number
US07691877B2

Reaction notes

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