참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzylamine | HCID 7504 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Chloro-3-nitro-1,2-dihydropyridin-2-one | HCID 519282 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | HCID 178526800 | HCID 178526800 | 67.6% |
반응 단계
4-chloro-3-nitro-2-pyridone (5 g, 28.65 mmol) was suspended in 150 mL of acetonitrile then benzylamine (3.15 mL, 28.65 mmol) was added followed by potassium carbonate (4 g, 28.65 mmol) and the mixture was stirred at 60° C. overnight. The solvent was removed in vacuo and the residue was suspended in water (200 mL). A solution of HCl 2M was added until pH˜6. The precipitate was filtered and dried in vacuo to give 4.75g of the title compound as a beige solid. A second crop from the mother liquids provided 1.4 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07691877B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_04 |
|---|
| ORD ID | ord-8208b30e7c9941e7836a2510317601ff |
|---|
| 출처 메모 | uspto-grants-2010_04 |
|---|
