Nitric Acid → HCID 178433492, compound

HRID 639693Notes

Reaction equation

HRID 639693 reaction equation
[CH3:1][C:2]1[C:3]([OH:10])=[CH:4][C:5]([OH:9])=[N:6][C:7]=1[CH3:8].[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[CH3:1][C:2]1[C:3]([OH:10])=[C:4]([N+:11]([O-:13])=[O:12])[C:5]([OH:9])=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 178433472HCID 178433472, compound

Product 1

HCID 178433492HCID 178433492, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
0 °C

Procedure

5,6-Dimethyl-pyridin-2,4-diol (6.5 g, 47 mmol) was stirred in 30 mL sulphuric acid and then cooled to 0° C. in an ice bath. Fuming nitric acid (10 mL) was added dropwise, and the mixture allowed to stir for 1 h after complete addition. The reaction mixture was poured onto crushed ice and the resulting yellow solid collected by filtration to give the title compound (3.9 g, 46%).

Workup

  1. additionafter complete addition
  2. additionThe reaction mixture was poured
  3. customonto crushed ice
  4. filtrationthe resulting yellow solid collected by filtration

Sources & evidence

ORD record
ord-17b245c24e9c478d9c7007d713b6ae7d
Source dataset
uspto-grants-2010_04
Patent number
US07691877B2

Reaction notes

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