Hydrochloric Acid → HCID 67455856, compound

Participants

Reaction Conditions

Reaction Steps

N2,N2-Diallyl-N4-benzyl-5,6-dimethyl-3-nitro-pyridine-2,4-diamine (828 mg, 2.4 mmol) was dissolved in ethanol (15 mL) and 2N HCl (15 mL) and iron powder (527 mg, 9.6 mmol) was added in one portion. The reaction mixture was heated at 70° C. for 2 h, and then cooled to room temperature and poured into 50 mL water. The resulting solution was neutralised with 1N NaOH solution to give a dark green suspension, which was extracted with EtOAc (2×25 mL) and the combined organics were dried over MgSO4, filtered and evaporated to give the title compound as a dark green oil (559 mg, 74%).

Provenance & Evidence