Ethylene Glycol → HCID 23131804, compound

HRID 639718Notes

Reaction equation

HRID 639718 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7].[OH-].[Na+].[CH2:13]([OH:16])[CH2:14][OH:15]>O>[OH:15][CH2:14][CH2:13][O:16][CH2:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7]

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 14798Sodium HydroxideHCID 71278253-(Bromomethyl)benzaldehyde

Product 1

HCID 23131804HCID 23131804, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
55 °C

Procedure

A mixture of 1.99 g of 3-(bromomethyl)benzaldehyde, 0.80 g of sodium hydroxide and 8 ml of ethylene glycol was heated at 55° C. for 6 hours. After water was added, the mixture was extracted with chloroform and then washed with an aqueous saturated sodium chloride solution. After dried over anhydrous sodium sulfate and then concentration under reduced pressure, the resulting residue was subjected to silica gel column chromatography to obtain 0.79 g of oily 3-[(2-hydroxyethoxy)methyl]benzaldehyde [Compound No. (g)].

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washwashed with an aqueous saturated sodium chloride solution
  3. dry with materialAfter dried over anhydrous sodium sulfate
  4. concentrationconcentration under reduced pressure

Sources & evidence

ORD record
ord-95da1e27b1bd47ec9a78dc0e122d5ead
Source dataset
uspto-grants-2010_04
Patent number
US07691883B2

Reaction notes

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