Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 4-Ethyl-5-pyridin-4-yl-4h-(1,2,4)triazole-3-thiol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-Ethyl-3-thiosemicarbazide | HCID 1551780 | — |
| 반응물 | Isonicotinoyl chloride hydrochloride | HCID 12262826 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 4-Ethyl-5-pyridin-4-yl-4h-(1,2,4)triazole-3-thiol | HCID 758273 | 58% |
반응 단계
The title compound (pale yellow solid, 16.7 g, 58%) was prepared from isonicotinoyl chloride hydrochloride (25.1 g, 140.8 mmol) and 4-ethyl-3-thiosemicarbazide (16.87 g, 141.5 mmol) in pyridine (185 ml) with sodium hydroxide (220 mL, 2M, 440 mmol) added to the intermediate formed to effect cyclization. 1H NMR (DMSO-d6) δ (ppm): 8.80 (dd, 2H), 7.72 (dd, 2H), 4.11 (q, 2H), 3.59 (t, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691892B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-756f7d3cce20469b8df1db71f4afabe3 |
| 출처 메모 | uspto-grants-2010_04 |