3,5-Difluorobenzoyl chloride → [5-(3,5-Difluoro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-yl]-methyl-amine

HRID 639785Notes

Reaction equation

HRID 639785 reaction equation
[CH3:1][NH:2][C:3]1[N:7](C)[C:6](C2C=CN=CC=2)=[N:5][N:4]=1.[F:15][C:16]1[CH:17]=[C:18]([CH:22]=[C:23]([F:25])[CH:24]=1)[C:19](Cl)=O>>[F:15][C:16]1[CH:17]=[C:18]([C:19]2[N:2]([CH3:1])[C:3]([NH:7][CH3:6])=[N:4][N:5]=2)[CH:22]=[C:23]([F:25])[CH:24]=1

Participants

3

Reactant 2

HCID 1456003,5-Difluorobenzoyl chlorideHCID 57837980Methyl-(4-methyl-5-pyridin-4-yl4H-[1,2,4]triazol-3-yl)-amine

Product 1

HCID 57837942[5-(3,5-Difluoro-phenyl)-4-methyl-4H-[1,2,4]triazol-3-yl]-methyl-amine

Procedure

The title compound was prepared according to the procedure for methyl-(4-methyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-amine (example 16a) from 3,5-difluoro-benzoyl chloride. 1H NMR (DMSO-D6) d (ppm): 2.83 (d, 3H) 3.41 (s, 3H) 6.20 (d, 1H) 7.35 (m, 3H),

Sources & evidence

ORD record
ord-c3ab9bc18cdc4fb69afd29c31fff6e20
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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