3-Pyridinecarbonyl chloride, hydrochloride (1:1) → 3-Pyridin-3-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine

HRID 639788Notes

Reaction equation

HRID 639788 reaction equation
N1[CH:6]=[CH:5][C:4]([C:7]2[N:11]3[CH2:12][CH2:13][CH2:14][NH:15][C:10]3=[N:9][N:8]=2)=[CH:3]C=1.Cl.C(Cl)(=O)C1C=CC=[N:20][CH:19]=1>>[N:20]1[CH:19]=[CH:6][CH:5]=[C:4]([C:7]2[N:11]3[CH2:12][CH2:13][CH2:14][NH:15][C:10]3=[N:9][N:8]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 1361179203-Pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine

Product 1

HCID 1360341853-Pyridin-3-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine

Procedure

The title compound is prepared according to the procedure for 3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine (example 17a) from nicotinoyl chloride hydrochloride.

Sources & evidence

ORD record
ord-df3af231f0d84ef9a9466ec61ed9cd8d
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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