3,5-Difluorobenzoyl chloride → 3-(3,5-Difluoro-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine

HRID 639789Notes

Reaction equation

HRID 639789 reaction equation
N1C=CC(C2[N:11]3[CH2:12][CH2:13][CH2:14][NH:15][C:10]3=[N:9][N:8]=2)=CC=1.[F:16][C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([F:26])[CH:25]=1)[C:20](Cl)=O>>[F:16][C:17]1[CH:18]=[C:19]([C:20]2[N:11]3[CH2:12][CH2:13][CH2:14][NH:15][C:10]3=[N:9][N:8]=2)[CH:23]=[C:24]([F:26])[CH:25]=1

Participants

3

Reactant 2

HCID 1456003,5-Difluorobenzoyl chlorideHCID 1361179203-Pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine

Product 1

HCID 1363432073-(3,5-Difluoro-phenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine

Procedure

The title compound is prepared according to the procedure for 3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine (example 17a) from 3,5-difluoro-benzoyl chloride.

Sources & evidence

ORD record
ord-81f35a55cb024a70b5c3ad3bdc93882f
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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