反应详情

温度

65 °C

4-Ethyl-5-pyridin-4-yl-2,4-dihydro-[1,2,4]triazole-3-thione (4.2 g, 20.4 mmol) was slowly added to Raney nickel (˜40 g, washed three times with 25 mL portions of ethanol) in ethanol (50 mL). The resulting mixture was stirred at 65° C. for approximately 28 hours. The solution mixture was carefully filtered and concentrated in vacuo to yield the title compound (2.88 g, 81.3%). 1H NMR (CDCl3) δ (ppm): 8.81 (d, 2H), 8.33 (s, 1H), 7.62 (d, 2H), 8.18 (q, 2H), 1.51 (t, 3H).

1. filtrationThe solution mixture was carefully filtered
2. concentrationconcentrated in vacuo