反应详情

A solution of 4-(4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine (2.55 g, 14.6 mmol) in 37% formaldehyde (˜12 mL) was stirred at 37° C. for 16 hours. Flash chromatography (10% methanolic ammonia in dichloromethane) yielded title product (2.55 g, 85%, used without further purification to remove remaining para-formaldehyde). 1H NMR (CDCl3) δ (ppm): 8.81 (d, 2H), 7.72 (d, 2H), 5.74 (t, 1H), 4.73 (d, 2H), 4.26 (q, 2H), 1.27 (t, 3H).