(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanol → 4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

HRID 639795Notes

Reaction equation

HRID 639795 reaction equation
[CH2:1]([N:3]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]1[CH2:14][OH:15])[CH3:2]>[O-2].[O-2].[Mn+4].ClCCl>[CH2:1]([N:3]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]1[CH:14]=[O:15])[CH3:2]

Participants

4

Reactant 1

HCID 68431190(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanol

Product 1

HCID 860676734-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Dichloromethane (4 mL) was added to a vial containing (4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-methanol (56.7 mg, 0.279 mmol) and manganese dioxide (364.3 mg, 4.19 mmol) was added. The vial was sealed and the reaction was allowed to stir for two hours. The reaction was filtered through celite and concentrated to yield the title compound. 1H NMR (CDCl3) δ (ppm): 10.21 (s, 1H), 8.88 (d, 2H), 7.63 (d, 2H), 4.45 (q, 2H), 1.48 (t, 3H).

Workup

  1. additionwas added
  2. customThe vial was sealed
  3. filtrationThe reaction was filtered through celite and
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-a3d56a31fdad4b38b1c27b576c108d9a
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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