4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol → 4-Methyl-5-pyridin-3-yl-4H-[1,2,4]triazole-3-carbaldehyde

HRID 639796Notes

Reaction equation

HRID 639796 reaction equation
[CH2:1]([N:3]1C=NN=C1C1C=CN=CC=1)C.[CH2:14]([N:16]1[C:20]([C:21]2[CH:26]=[CH:25]N=C[CH:22]=2)=[N:19][N:18]=[C:17]1[CH2:27][OH:28])C.C(N1C(C2C=CN=CC=2)=NN=C1C=O)C.CN1C(C2C=NC=CC=2)=NNC1=S>>[CH3:14][N:16]1[C:20]([C:21]2[CH:22]=[N:3][CH:1]=[CH:25][CH:26]=2)=[N:19][N:18]=[C:17]1[CH:27]=[O:28]

Participants

5

Reactant 4

HCID 7575824-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiolHCID 544930004-(4-Ethyl-4H-[1,2,4]triazol-3-yl)-pyridineHCID 68431190(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanolHCID 860676734-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

Product 1

HCID 833833244-Methyl-5-pyridin-3-yl-4H-[1,2,4]triazole-3-carbaldehyde

Procedure

The title compound is prepared analogously to the sequence described for 4-(4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine (example 21), (4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-methanol (example 22), and 4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde (example 23a) by using 4-methyl-5-pyridin-3-yl-2,4-dihydro-[1,2,4]triazole-3-thione as starting material.

Sources & evidence

ORD record
ord-5cdbdd6e4e2d44dbba3fb7238d9eb91f
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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