4-(4-Ethyl-4H-[1,2,4]triazol-3-yl)-pyridine → 5-(3,5-Difluoro-phenyl)-4-methyl-4H-[1,2,4]triazole-3-carbaldehyde

HRID 639797Notes

Reaction equation

HRID 639797 reaction equation
C(N1C=NN=C1C1C=CN=CC=1)C.C(N1C(C2C=CN=CC=2)=NN=C1[CH2:27][OH:28])C.C(N1C(C2C=CN=CC=2)=NN=C1C=O)C.[F:44][C:45]1[CH:46]=[C:47]([C:52]2[N:53]([CH3:58])[C:54](=S)[NH:55][N:56]=2)[CH:48]=[C:49]([F:51])[CH:50]=1>>[F:44][C:45]1[CH:46]=[C:47]([C:52]2[N:53]([CH3:58])[C:54]([CH:27]=[O:28])=[N:55][N:56]=2)[CH:48]=[C:49]([F:51])[CH:50]=1

Participants

5

Reactant 4

HCID 544930004-(4-Ethyl-4H-[1,2,4]triazol-3-yl)-pyridineHCID 68431190(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanolHCID 703281195-(3,5-Difluoro-phenyl)-4-methyl-2,4-dihydro-[1,2,4]triazole-3-thioneHCID 860676734-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

Product 1

HCID 860676765-(3,5-Difluoro-phenyl)-4-methyl-4H-[1,2,4]triazole-3-carbaldehyde

Procedure

The title compound is prepared analogously to the sequence described for 4-(4-ethyl-4H-[1,2,4]triazol-3-yl)-pyridine (example 21), (4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-methanol (example 22), and 4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde (example 23a) by using 5-(3,5-Difluoro-phenyl)-4-methyl-2,4-dihydro-[1,2,4]triazole-3-thione as starting material.

Sources & evidence

ORD record
ord-147efc5ca17a4fd48e573dca337ea308
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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