HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → 3-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]butan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 2-(3-{[tert-butyl(dimethyl)silyl]oxy}-1-methylpropyl)-5-(3-chlorophenyl)-2H-tetrazole | HCID 68431875 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-[5-(3-chlorophenyl)-2H-tetrazol-2-yl]butan-1-ol | HCID 68429601 | 91% |
Reaction Steps
TBAF was added to a solution of 2-(3-{[tert-butyl(dimethyl)silyl]oxy}-1-methylpropyl)-5-(3-chlorophenyl)-2H-tetrazole in THF (25 mL). The mixture was concentrated after 4 h and the crude was purified by flash column chromatography (SiO2, Heptane-EtOAc 1:1) to give 0.90 g (91%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691892B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-b3459ad394b14bbaab9ff185ff823a46 |
| Source note | uspto-grants-2010_04 |