Succinic Acid → HCID 86620199, compound

Participants

Reaction Steps

To 300.7 mg of (1S,6R)-6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane (E2a) and 123.4 mg of succinic acid, 0.5 mL of isopropylalcohol (IPA) was added with stirring. A further 0.5 mL was added and heat applied using an air gun to aid dissolution. Further solvent additions of 2×0.5 mL, 1 mL, 0.5 mL and 1 mL were added to achieve a mobile slurry (giving a total solvent volume of 4.5 mL IPA added). The resulting slurry was temperature cycled between 0 and 40° C. for three days. The sample was then filtered and the solid title compound obtained dried under vacuum at 70° C. for 24 hours.

Provenance & Evidence