HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(aminomethyl)-6-methoxy-4-phenylisoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 6-Methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile | HCID 11242851 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(aminomethyl)-6-methoxy-4-phenylisoquinolin-1(2H)-one | HCID 68518088 | 87.7% |
Reaction Steps
To a solution of 6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile (200 mg) in 40 mL ethanol were added Raney Ni and 4 mL of 2 M ammonia in methanol. The reaction was shaken under 50 psi H2 pressure overnight. The reaction was filtered and concentrated to give 178 mg of 3-(aminomethyl)-6-methoxy-4-phenylisoquinolin-1(2H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691879B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-c4d84084a62a419586bf8a714d351940 |
| Source note | uspto-grants-2010_04 |