化工社化工社 化学情報印刷レポート · 研究参考用
Phosphorus oxychloride → 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 3-[(dimethylamino)methyl]-6-methoxy-4-phenylisoquinolin-1(2H)-one | HCID 68519114 | — |
| 生成物 | 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine | HCID 11738916 | — |
反応手順
3-[(dimethylamino)methyl]-6-methoxy-4-phenylisoquinolin-1(2H)-one (50 mg) was combined with 0.600 mL of POCl3, and the reaction was stirred at 90 C for 1 h. After cooling, the reaction was partitioned between saturated aqueous sodium bicarbonate and EtOAc. The organic solution was dried over Na2SO4 and concentrated. Flash chromatography (3% MeOH in CH2Cl2) gave the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691879B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-1946815f0b0243388838f3a99a4baa43 |
| 出典メモ | uspto-grants-2010_04 |