Ethanolamine → HCID 11415597, compound

Participants

Reaction Steps

1-chloro-6-methoxy-3-methyl-4-phenylisoquinoline (0.29 g) was combined with 10 mL of ethanolamine and heated at 120 C for 5 h, then cooled to room temp. The reaction was poured into saturated aqueous sodium carbonate and extracted with EtOAc (3×). The combined organic solutions were washed with water (1×), then dried (Na2SO4) and concentrated. Flash chromatography (10% MeOH/CHCl2) gave a solid which was recrystallized from ether/hexanes to give the titled compound.

Provenance & Evidence