Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → HCID 11196248, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 1-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile | HCID 11426414 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Pd barium sulfate | HCID 16218511 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 11196248 | HCID 11196248 | — |
반응 단계
A mixture of 1-chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile (200 mg), 5% Pd/BaSO4 (50 mg), and 20 mL methanol was stirred under 1 atm hydrogen for 18 h. 5 mL of CH2Cl2 was then added, as was an additional 50 mg Pd/BaSO4. After stirring overnight, the reaction was filtered, concentrated, and purified by flash chromatography (30% EtOAc/hexanes) to give the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691879B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-21122a785cfe4cf4b7c43b8448b56566 |
| 출처 메모 | uspto-grants-2010_04 |