(1-methyl-1H-imidazol-4-yl)methanol → HCID 11372648, compound

HRID 639904Notes

Reaction equation

HRID 639904 reaction equation
C(OC1C2C(=CC(OC)=CC=2)C(C2C=CC=CC=2)=C(C#N)N=1)C=C.Cl[C:26]1[C:35]2[C:30](=[CH:31][C:32]([O:36][CH3:37])=[CH:33][CH:34]=2)[C:29]([C:38]2[CH:43]=[CH:42][CH:41]=[C:40]([F:44])[CH:39]=2)=[C:28]([C:45]#[N:46])[N:27]=1.[CH3:47][N:48]1[CH:52]=[C:51]([CH2:53][OH:54])[N:50]=[CH:49]1>>[F:44][C:40]1[CH:39]=[C:38]([C:29]2[C:30]3[C:35](=[CH:34][CH:33]=[C:32]([O:36][CH3:37])[CH:31]=3)[C:26]([O:54][CH2:53][C:51]3[N:50]=[CH:49][N:48]([CH3:47])[CH:52]=3)=[N:27][C:28]=2[C:45]#[N:46])[CH:43]=[CH:42][CH:41]=1

Participants

4

Reactant 3

HCID 7060524(1-methyl-1H-imidazol-4-yl)methanolHCID 112438971-Chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrileHCID 114384741-(Allyloxy)-6-methoxy-4-phenylisoquinoline-3-carbonitrile

Product 1

HCID 11372648HCID 11372648, compound

Procedure

Following the procedure for 1-(allyloxy)-6-methoxy-4-phenylisoquinoline-3-carbonitrile, using 1-chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile in place of 1-chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile and (1-methyl-1H-imidazol-4-yl)methanol in place of allyl alcohol, the title compound was synthesized.

Sources & evidence

ORD record
ord-d5032bc195b74a06b2261e6709f05a68
Source dataset
uspto-grants-2010_04
Patent number
US07691879B2

Reaction notes

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