HuagongsheHuagongshe Chemistry Print Report · For research reference only
Serinol → HCID 11440023, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Serinol | HCID 68294 | — |
| Reactant | 1-Chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile | HCID 11243897 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 11440023 | HCID 11440023 | — |
Reaction Steps
A suspension of 1-chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile (50 mg) and [2-hydroxy-1-(hydroxymethyl)ethyl]amine (146 mg) in 2 mL isopropanol was heated at 160 C in a microwave reactor for 8 h. The reaction was concentrated and purified by flash chromatography (0% to 5% MeOH in EtOAc) to give a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691879B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-29c86a94df954061a82e49ca0b2f79cb |
| Source note | uspto-grants-2010_04 |