HCID 11360073, compound → HCID 11418261, compound

HRID 639916Notes

Reaction equation

HRID 639916 reaction equation
O[C@H](CO)COC1C2C(=CC(OC)=CC=2)C(C2C=CC=CC=2)=C(C#N)N=1.CC1(C)[O:32][C@H:31]([CH2:33][O:34][C:35]2[C:44]3[C:39](=[CH:40][C:41]([O:45][CH:46]([F:48])[F:47])=[CH:42][CH:43]=3)[C:38]([C:49]3[CH:54]=[CH:53][CH:52]=[C:51]([F:55])[CH:50]=3)=[C:37]([C:56]#[N:57])[N:36]=2)[CH2:30][O:29]1>>[F:48][CH:46]([F:47])[O:45][C:41]1[CH:40]=[C:39]2[C:44](=[CH:43][CH:42]=1)[C:35]([O:34][CH2:33][C@@H:31]([OH:32])[CH2:30][OH:29])=[N:36][C:37]([C:56]#[N:57])=[C:38]2[C:49]1[CH:54]=[CH:53][CH:52]=[C:51]([F:55])[CH:50]=1

Participants

3

Reactant 2

HCID 11360073HCID 11360073, compoundHCID 68518322HCID 68518322, compound

Product 1

HCID 11418261HCID 11418261, compound

Procedure

Following the procedure for 1-{[(2R)-2,3-dihydroxypropyl]oxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, using 1-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-6-(difluoromethoxy)-4-(3-fluorophenyl)isoquinoline-3-carbonitrile in place of 1-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrile, the title compound was synthesized.

Sources & evidence

ORD record
ord-5260f1fc6a5f4529962ba2304db529aa
Source dataset
uspto-grants-2010_04
Patent number
US07691879B2

Reaction notes

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