Phosphorus oxychloride → HCID 86609504, compound

Participants

Reaction Conditions

Reaction Steps

POCl3 (22 mg, 0.15 mmol) was added to 4-(3-fluorophenyl)-1-hydroxy-6-pyridin-2-ylisoquinoline-3-carbonitrile (50 mg, 0.15 mmol) neat. The resulting mixture was heated to 90° C. for 18 h. The reaction was cooled to room temperature and diluted with H2O (10 mL). This was brought to a pH of 9 with NaHCO3. The aqueous layer was extracted with EtOAc. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated to yield the title compound as a brown oil.

Provenance & Evidence