HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Hydroxy-4-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Methoxysalicylic Acid | HCID 75231 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Hydroxy-4-methoxybenzoyl chloride | HCID 23118559 | — |
Reaction Steps
To a solution of 2-hydroxy-4-methoxybenzoic acid (20 g, 118.9 mmol) in 500 mL CH2Cl2 was added thionyl chloride (21.2 g, 178.4 mmol), followed by 0.4 mL DMF. After stirring at rt for 8 h, the reaction mixture was concentrated to a white solid (azeotroped twice from benzene). This material was used as is in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691879B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-ecf2ec74ab534a90a544406e79f18c91 |
| Source note | uspto-grants-2010_04 |