Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | HCID 86041274 | HCID 86041274 | — |
| Reactant | HCID 178418800 | HCID 178418800 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | Ammonia methanol | HCID 21705897 | 0% |
| Product | HCID 68518318 | HCID 68518318 | — |
Reaction Steps
1,4-dichloro-6-methoxyisoquinoline-3-carbonitrile (0.25 g, 0.988 mmol) and 4-methylimidazole (0.324 g 3.951 mmol) and 4 mL isopropanol were taken in a sealed tube and heated at 150° C. for 2 h The resulting white solid was dissolved in hot EA-MeOH and dry loaded on a flash column. Flash chromatography (0% to 6% MeOH—NH3 in EA) gave the titled compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07691879B2 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-b3a0441977184bf8bc1abb4689026e82 |
|---|
| Source note | uspto-grants-2010_04 |
|---|
