Potassium Phosphate, Tribasic → HCID 58767470, compound

Participants

Reaction Conditions

Reaction Steps

4-chloro-6-methoxy-1-(4-methyl-1H-imidazol-1-yl)isoquinoline-3-carbonitrile (0.055 g, 0.184 mmol), 3-pyridylboronic acid (0.034 g, 0.276 mmol), Pd2(dba)3 (0.017 g, 0.018 mmol), tricyclohexylphosphene (0.015 g, 0.055 mmol) and K3PO4 (0.117 g, 0.552 mmol) were taken in 7 mL dry dioxane and heated at 100° C. under argon atmosphere for 22 h. The reaction mixture was filtered through celite and concentrated. To the resulting residue all of the above reagents and 6 mL dioxane were added and then the mixture was heated at 100° C. for 22 h. The reaction was cooled to rt, filtered through celite (washing with CH2Cl2) and the filtrate was concentrated, then purified by flash chromatography: 3% to 6% MeOH—NH4OH (90:10, v/v) in EtOAc. Irnpure fractions from the flash chromatography were combined and purified by reverse phase HPLC to give a white solid (0.025 g, 40%).

Provenance & Evidence