HCID 86620235, compound → HCID 86620236, compound

HRID 639941Notes

Reaction equation

HRID 639941 reaction equation
[CH2:1]([O:3][P:4]([CH2:9][C:10]1[CH:15]=[C:14]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:11]=1[O:25]CC1C=CC=CC=1)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]>CO.[Pd]>[CH2:6]([O:5][P:4]([CH2:9][C:10]1[CH:15]=[C:14]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH3:24])=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:11]=1[OH:25])(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

Participants

4

Reactant 1

HCID 86620235HCID 86620235, compound

Product 1

HCID 86620236HCID 86620236, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of [2-benzyloxy-5-(4-ethylbenzyl)benzyl]phosphonic acid diethylester (1.03 g) in methanol (10.0 mL) was added 5% Pd—C (0.10 g), and the reaction mixture was stirred for 5 hr at room temperature under hydrogen gas atmosphere. After filtration and evaporation, the residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=2/3) to give the title compound (0.80 g) as a colorless oil.

Workup

  1. filtrationAfter filtration and evaporation
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=2/3)

Sources & evidence

ORD record
ord-7a9c4819e15e4f15938bf6a89c9e486d
Source dataset
uspto-grants-2010_04
Patent number
US07691898B2

Reaction notes

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