HCID 86620239, compound → HCID 86620240, compound

HRID 639947Notes

Reaction equation

HRID 639947 reaction equation
[CH2:1]([O:3][P:4]([CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH3:25])=[CH:20][CH:19]=2)[CH:14]=[CH:13][C:12]=1[O:26]CC1C=CC=CC=1)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]>CO.[Pd]>[CH2:6]([O:5][P:4]([CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([CH2:24][CH3:25])=[CH:22][CH:23]=2)[CH:14]=[CH:13][C:12]=1[OH:26])(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

Participants

4

Reactant 1

HCID 86620239HCID 86620239, compound

Product 1

HCID 86620240HCID 86620240, compoundYield 90.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-[2-benzyloxy-5-(4-ethylbenzyl)phenyl]ethylphosphonic acid diethylester (0.71 g) in methanol (7.0 mL) was added 5% Pd—C (0.07 g), and the reaction mixture was stirred for 4.5 hr at room temperature under a hydrogen gas atmosphere. After filtration and evaporation, the residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=2/3) to give the title compound (0.52 g) as a colorless oil.

Workup

  1. filtrationAfter filtration and evaporation
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=2/3)

Sources & evidence

ORD record
ord-1a01c1d1fd884c1a91c00d3215414d30
Source dataset
uspto-grants-2010_04
Patent number
US07691898B2

Reaction notes

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