Triethyl phosphite → HCID 86620243, compound

HRID 639951Notes

Reaction equation

HRID 639951 reaction equation
[P:1]([O:8][CH2:9][CH3:10])([O:5][CH2:6][CH3:7])[O:2]CC.[CH2:11]([O:13][C:14]1[CH:28]=[CH:27][C:17]([CH2:18][C:19]2[S:23][C:22]([C:24](Cl)=[O:25])=[CH:21][CH:20]=2)=[CH:16][CH:15]=1)[CH3:12]>>[CH2:9]([O:8][P:1]([C:24]([C:22]1[S:23][C:19]([CH2:18][C:17]2[CH:16]=[CH:15][C:14]([O:13][CH2:11][CH3:12])=[CH:28][CH:27]=2)=[CH:20][CH:21]=1)=[O:25])(=[O:2])[O:5][CH2:6][CH3:7])[CH3:10]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 86235364HCID 86235364, compound

Product 1

HCID 86620243HCID 86620243, compound

Procedure

Triethyl phosphite (1.3 mL) was added to 5-(4-ethoxybenzyl)thiophen-2-carbonylchloride (1.10 g), and the mixture was stirred for 22 hr at room temperature. After evaporation, the residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=2/1) to give the title compound (0.54 g) as a pale yellow oil.

Workup

  1. customAfter evaporation
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate/n-hexane=2/1)

Sources & evidence

ORD record
ord-0da5675a7a2948c2a36a1a6f3bd14cf3
Source dataset
uspto-grants-2010_04
Patent number
US07691898B2

Reaction notes

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