Ammonium formate → 6-Methoxy-7-hydroxyquinazolin-4-one

Participants

Reaction Steps

Palladium on carbon (3.3 g of a 10% mixture) was added to a solution of 7-(benzyloxy)-6-methoxyquinazolin-4-(3H)-one (20 g, 71 mmol) (prepared according to J. Med. Chem. 1999, 42, 5369-5389) was suspended in dimethylformamide (530 ml). Ammonium formate (45 g, 710 mmol) was then added portion wise over 1.25 hours. The reaction mixture was stirred for an additional 0.5 hours and the catalyst was removed by filtration. The solvent was removed in vacuo to yield 7-hydroxy-6-methoxyquinazolin-4-(3H)-one (8.65 g, 64% yield):

Provenance & Evidence