Benzyl Alcohol → 7-(Benzyloxy)-3,4-dihydroquinazolin-4-one

Participants

Reaction Conditions

Reaction Steps

Sodium (10.3 g, 0.45 mol) was added to benzyl alcohol (200 ml, 1.94 mol) under argon and the mixture heated at 120° C. for 4 hours. 7-Fluoroquinazolin-4-(3H)-one (15 g, 90 mmol) was added to the mixture and the reaction heated at 120° C. for 18 hours. The mixture was cooled, poured into water (800 ml) and the pH adjusted to 4 with hydrochloric acid (2 N, 150 ml). The resultant precipitate was collected by filtration, washed with water, pentane and diethyl ether to yield 7-(benzyloxy)quinazolin-4-(3H)-one (22.3 g, 98% yield):

Provenance & Evidence