Ammonia → HCID 178513854, compound

HRID 639971Notes

Reaction equation

HRID 639971 reaction equation
[N+:1]([C:4]1[C:5]([C:9]([O:11]CC)=O)=[N:6][NH:7][CH:8]=1)([O-:3])=[O:2].[NH3:14]>>[N+:1]([C:4]1[C:5]([C:9]([NH2:14])=[O:11])=[N:6][NH:7][CH:8]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178470496HCID 178470496, compound

Product 1

HCID 178513854HCID 178513854, compoundYield 86%

Procedure

Ethyl 4-nitro-1H-pyrazole-3-carboxylate (741 mg, 4 mmol) was heated at 90° C. with a concentrated solution of aqueous ammonia (28%, 20 ml) in a sealed vessel for 3 hours. The mixture was evaporated and the residue was triturated with diethyl ether to give 4-nitro-1H-pyrazole-3-carboxamide (0.54 g, 86% yield) as a white solid:

Workup

  1. customThe mixture was evaporated
  2. customthe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-952729dc0feb4d47846e6658ca9c244f
Source dataset
uspto-grants-2010_04
Patent number
US07691867B2

Reaction notes

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