反应详情

[7-(benzyloxy)-5-isopropoxy-4-oxoquinazolin-3(4H)-yl]methyl pivalate was stirred in a 7N solution of ammonia in methanol (250 ml) at room temperature for 24 hours. The mixture was evaporated under reduced pressure and the residue purified by silica gel chromatography eluting with a 0 to 10% mixture of methanol in dichloromethane to give 7-(benzyloxy)-5-isopropoxyquinazolin-4(3H)-one (4.6 g, 87% yield over 2 steps) as a white solid:

1. customThe mixture was evaporated under reduced pressure
2. customthe residue purified by silica gel chromatography
3. washeluting with a 0 to 10% mixture of methanol in dichloromethane